(Principal) Lead Scientist, BioAI at Novo Nordisk

Your new role

As (Principal) Lead Scientist, you will perform cutting edge analyses of cellular phenotype data derived from ultra-high throughput genetic and compound screens to identify new drug targets for cardiometabolic disease. You will have direct impact on our early pipeline and lead the scientific deliveries from our flagship genome-scale in-vitro perturbation screens producing high-content imaging and functional genomics data and help us translate these into compelling drug projects. This is a senior scientific role in which you will have the opportunity to have major impact on our early pipeline and engage directly with senior therapy area disease experts, computational biologists, and engineering teams. 

Your responsibilities will include: 

• Scientific leadership and execution of high-value AI and data analysis projects for target discovery
• Translation of ultra-high throughput in-vitro screening analysis results/insights into drug target candidates and pipeline projects  
• Systems biology-guided interrogation of high-dimensional cell-painting embeddings & omics (incl. DRUG-seq/perturb-seq) data derived from genetic & chemical perturbations
• Keep pace with cutting edge biology-focused AI methods and contribute to the development of internal evaluations/benchmarks to keep our models focused on value to our discovery pipeline 
• Develop collaborative and strategic relationships with key stakeholders in our therapy areas to ensure alignment with the global Novo Nordisk drug discovery strategy and portfolio
• Provide input to our overall systems biology strategy, including scientific direction and implementation

The role requires up to 10% overnight travel, potentially international.

Your new department  

• You will join the BioAI department, part of AI and Digital Innovation in Research & Development (R&D).  BioAI is a global department with colleagues in Denmark, the United Kingdom, and the United States. Our scientists have significant expertise across a diverse set of disciplines in machine learning, graph data science, computer vision, and agentic reasoning, all applied to impacting early target discovery. Driving data-first decision making in our R&D pipeline is a key objective for BioAI as we seek to strengthen the Novo Nordisk portfolio and deliver new medicines for patients across our core cardiometabolic disease areas.

Your skills & qualifications
To succeed in the role, we expect you to have: 

• Master’s degree is a must, and PhD is strongly preferred in cellular/molecular/computational biology or similar preferably combined with several years of experience in a pharma/tech bio context
• Scientific leadership experience in cross-functional teams with a track record of progressing novel biological hypotheses, ideally focused on drug target identification within a pharma industry context 
• Experience applying cutting edge AI and systems biology methods to generate, analyse, and interpret high-dimensional datasets, preferably from HCI/omics data on in-vitro genetic/compound screens 
• Independence and motivation to perform in-depth biology-focused data analysis and work with project and leadership teams to progress targets
• Experience working in Python/R to curate and analyse data 
• Experience in CMD-relevant cellular/molecular biology is an advantage
• Excellent written and oral communication skills, detail oriented with strong presentation and documentation skills